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LDL receptor-related protein plays diverse role in protease clearance
September 10th, 2003
LDL receptor-related protein plays a diverse role in the clearance of proteases and in signaling. "The low density lipoprotein receptor-related protein (LRP) is a large endocytic receptor that participates in several biological pathways and plays prominent roles in lipoprotein metabolism and in the catabolism of proteinases involved in coagulation and fibrinolysis. LRP also mediates the cellular entry of certain viruses and toxins and facilitates the activation of various lysosomal enzymes," scientists in the United States report. "Deletion of the LRP gene in mice is lethal, confirming an important role for this receptor in development, although its...
Source: Biotech Week (2003-09-10)
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