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Genesis Research & Development
Genome-based screening approach to vaccine development designed
September 10th, 2003
Researchers have designed a genome-based functional screening approach to vaccine development that combines in vitro assays and DNA immunization. "A two-step screening strategy was developed to identify strong immunogenic polypeptides with putative vaccine and/or adjuvant activity," scientists in New Zealand report. "In the first step, a mycobacterial genomic DNA library was screened in vitro to identify plasmids encoding polypeptides that stimulate splenocytes from mycobacteria-immunized mice and T cells from PPD-positive healthy donors to produce interferon-gamma," stated Alain Delcayre and colleagues at Genesis Research and Development. "In the...
Source: Biotech Week (2003-09-10)
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