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Genetics Assays, Inc.
TMSI methylation may play a role in the pathogenesis of lung and breast cancer
September 10th, 2003
TMSI methylation may play a role in the pathogenesis of lung and breast cancer. "TMSI (target of methylation-induced silencing) is a CpG island-associated gene that functions in the regulation of apoptosis and encodes a caspase recruitment domain, a recently described motif found in apoptotic signaling molecules," researchers in the United States report. "Recent evidence suggests that silencing of genes in the apoptotic pathway contributes to human carcinogenesis. We examined the DNA methylation status of the TMSI promoter in lung and breast tumor tissues, tumor cell lines, and nonmalignant tissues by methylation-specific polymerase chain reaction...
Source: Biotech Week (2003-09-10)
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