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Center University of Orsay
Huntingtin signaling pathways regulate toxicity in Huntington disease
January 14th, 2004
Scientists investigate huntingtin phosphorylation and signaling pathways that regulate toxicity in Huntington's disease in a recent issue of Clinical Neuroscience Research. According to recent research from France, "Despite an intensive research on the protein huntingtin that causes Huntington disease, little is known about the dysregulation of signal transduction pathways and their role in the pathological process. PolyQ expansion in huntingtin causes the activation of various pathways that may participate in cell death. Of particular interest is the role of the mitogen activated protein kinases." "In addition, modification of huntingtin by...
Source: Biotech Week (2004-01-14)
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