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Centers for Disease Control & Prevention



Opsonophagocytosis assay effective for Streptococcus pneumoniae antibodies



January 14th, 2004

Scientists have developed an opsonophagocytosis assay for measurement of opsonophagocytic antibodies specific to the capsular polysaccharides of Streptococcus pneumoniae.

"Opsonophagocytosis is a correlate of protection that measures the functional activity of vaccine-induced antibodies. A standardized opsonophagocytosis assay (OPA) should be used as part of the evaluation of current and future pneumococcal (Pnc) polysaccharide (Ps)-based vaccines. We enrolled five laboratories to evaluate a previously standardized viability OPA," scientists writing in the journal Clinical and Diagnostic Laboratory Immunology report.

"Each laboratory...


Source: Biotech Week (2004-01-14)

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