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Chiba University
Amiodarone inhibits only sarcolemmal K-ATP channels in ventricular cells
January 14th, 2004
Amiodarone inhibits ventricular cell sarcolemmal - but not mitochondrial - K-ATP channels. "ATP-sensitive K+ (K-ATP) channels are present on the sarcolemma (sarcKATP channels) and mitochondria (mitoKATP channels) of cardiac myocytes," scientists in Japan noted. "Amiodarone, a class III antiarrhythmic drug, reduces sudden cardiac death in patients with organic heart disease." T. Sato and colleagues at Chiba University conducted a study "to investigate the effects of amiodarone on sarcKATP and mitoKATP channels." "Single sarcKATP channel current and flavoprotein...
Source: Biotech Week (2004-01-14)
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