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Children's Hospital of Philadelphia



Targeting of chemokine receptors may help stop allograft rejection



January 14th, 2004

Targeting of chemokine receptors may be of greater use in stopping allograft rejection than current immunosuppressive therapy.

According to a study from the United States, "immunologists have typically viewed alloreactivity schematically as a function of antigen presentation, expansion of alloreactive T and B cells within regional lymphoid tissues, and cellular infiltration and destruction of an allograft.

"Actual details of the steps between immune activation and accumulation of effector cells within a graft typically have not received much attention. However, just how cells know to move to and migrate within a graft or not is proving to be of...


Source: Biotech Week (2004-01-14)

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