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Children's Hospital, Westmead
Changes in the noradrenergic system underlie anorexia nervosa risk
January 14th, 2004
Changes in the noradrenergic system underlie anorexia nervosa risk. "We earlier found an association between anorexia nervosa (AN) restrictive subtype (AN-R) and an inserted sequence within the NETpPR, a polymorphic region located in the promoter of the solute carrier family 6 ( neurotransmitter transporter, noradrenalin) member 2 (SLC6A2) gene. To further examine the noradrenergic system in AN-R we performed an association study with a functional polymorphism (MAOA-uVNTR) in the promoter of the monoamine oxidase A (MAOA) gene. Since monoamine oxidase A metabolizes noradrenalin, a positive association with the MAOA gene would be biologically plausible," investigators in...
Source: Biotech Week (2004-01-14)
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