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Chinese University of Hong Kong
Thrombospondin-1 causes leukemia cells to self-destruct
January 14th, 2004
Thrombospondin-1 causes leukemia cells to self-destruct. According to published research from the People's Republic of China, "thrombospondin-1 (TSP-1) is a naturally occurring antiangiogenic compound that induces apoptosis of endothelial and cancer cells via its receptor CD36. The objectives of our study were to investigate the in vitro effects of TSP-1 on the apoptosis of primary human leukemia cells as well as leukemia cell lines and the possible mechanism involving CD36." "Our results demonstrated that TSP-1 induced apoptosis in CD36 positive cell lines CHRF-288-11, Meg-01 and HL-60, but not CD36 negative K562, at a dose-dependent manner as...
Source: Biotech Week (2004-01-14)
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