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BioVex Ltd
Herpes simplex virus vectors create transgene persistence in motor neurons
September 1st, 2004
Herpes simplex virus vectors create transgene persistence in motor neurons. According to recent research from England, "the use of viral vectors for gene delivery to motor neurons in vivo has been hampered by the need to perform invasive surgery to inject directly the vector into the anterior horn of the spinal cord. Here, we have characterized the features of herpes simplex virus-1 (HSV)-derived vectors in terms of gene mutations and promoter constructs, that are required to allow efficient transduction of motor neurons following a relatively noninvasive peripheral administration via sciatic nerve or footpad injection." "Owing to the wide variety of...
Source: Biotech Week (2004-09-01)
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