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Aarhus University of Hospital

Carbohydrate intolerance in cirrhosis is determined by insulin resistance

"It is well established that subjects with liver cirrhosis are insulin resistant, but the contribution of defects in insulin secretion and/or action to glucose intolerance remains unresolved. Healthy individuals and subjects with liver cirrhosis were studied on two occasions: 1) an oral glucose tolerance test was performed, and 2) insulin secretion was inhibited and glucose was infused in a pattern and amount mimicking the systemic delivery rate of glucose after a carbohydrate meal," scientists in Denmark reported recently in the American Journal of Physiology - Gastrointestinal and...