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M.D. Anderson Cancer Center
Research add new data to gene silencing body of knowledge
July 6th, 2005
New findings from the United States and People's Republic of China describe advances in gene silencing. Study 1: STAT3 knockdown shutters breast tumor formation in murine models. According to a study from the United States, "constitutively activated STAT3 is involved in the formation of multiple types of tumors including breast cancer. We examined the effects of Stat3 protein knockdown by RNA interference using a dicistronic lentivirus small hairpin (shRNA) delivery system on the growth of mammary tumors in BALB/c mice induced by the 4T1 cell line." "A single exposure of 4T1 cells to shRNA/STAT3 lentivirus transduced 75% of the...
Source: Biotech Week (2005-07-06)
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