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U.S. National Institutes of Health
Reports advance knowledge in immunology research
July 6th, 2005
Reports from the United States and People's Republic of China highlight recent research on immunology. Study 1: Antigen receptor requires caspase-8 for NF-kappa B activation. According to a study from the United States and Canada, "Caspase-8, a pro-apoptotic protease, has an essential role in lymphocyte activation and protective immunity. We show that caspase-8 deficiency (CED) in humans and mice specifically abolishes activation of the transcription factor nuclear factor kappaB (NF-kappaB) after stimulation through antigen receptors, Fc receptors, or Toll-like receptor 4 in T, B, and natural killer cells. Caspase-8 also causes the up complex of the...
Source: Biotech Week (2005-07-06)
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