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Aarhus University Hospital
AGE-RAGE and AGE important in pathogenesis of diabetic nephropathy
August 10th, 2005
AGE-RAGE and AGE are important players in the pathogenesis of diabetic kidney disease. According to a study from Denmark, "At present, diabetic kidney disease affects about 15-25% of all type 1 diabetic patients and 20-40% of all patients with type 2 diabetes. The mechanisms underlying the development of diabetic kidney disease are extremely complex and not yet fully understood. Among the many potential pathogenic mechanisms responsible for the progression in diabetic kidney disease, the involvement of metabolic factors beyond blood glucose, such as advanced glycation end products (AGEs), has been suggested." "This review will present the emerging...
Source: Biotech Week (2005-08-10)
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