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Adnan Menderes University of Hastanesi, Aydin
Haemophilus influenzae cefotaxime resistance involves altered binding proteins
May 8th, 2006
According to research from Turkey, Haemophilus influenzae cefotaxime resistance involves altered penicillin binding proteins (PBPs). "Resistance to beta-lactams in H. influenzae is mostly due to the presence of TEM beta-lactamases. Beta-lactamase-negative ampicillin resistance (BLNAR) also occurs as a result of PBP3 modifications. BLNAR strains are particularly common in Japan and France, and strains with combined mechanisms of altered PBP3 and beta-lactamase (BLPACR) are emerging. "Although the prevalence of beta-lactamase-positive strains is high, TEM-derived extended-spectrum beta-lactamase (ESBL)-mediated cephalosporin resistance,...
Source: Biotech Week (2006-05-08)
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