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Aichi Cancer Center
Acute promyelocytic leukemia not linked to chromosomal imbalances
May 8th, 2006
Acute promyelocytic leukemia (APL) was largely unrelated to chromosomal imbalances. According to recent research from Japan, "APL is typically associated with the t(15; 17) that generates the PML-RARA fusion protein. Animal models have shown that although the fusion protein is necessary, it is insufficient for the development of APL, implying that additional mechanisms are responsible for full-blown leukemia." "The mutation of specific genes has been implicated in leukemogenesis; however, alterations in gene copy number have not been well investigated. Here, we applied the genomewide array comparative genomic hybridization technique to 30 APL...
Source: Biotech Week (2006-05-08)
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