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Albert Einstein College of Medicine, Bronx
Biofilm formation may diminish antifungal efficacy during cryptococcal infection
May 8th, 2006
Biofilm formation may diminish antifungal efficacy during cryptococcal infection. According to a recent report from the United States, "Microbial biofilms contribute to virulence and resistance to antibiotics by shielding microbial cells from host defenses and antimicrobial drugs, respectively. Cryptococcus neoformans was demonstrated to form biofilms in polystyrene microtiter plates. "The numbers of CFU of disaggregated biofilms, 2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-5-[(phenylamino)carbonyl]-2H-tetrazolium hydroxide reduction, and light and confocal microscopy were used to measure the fungal mass, the metabolic activity, and the...
Source: Biotech Week (2006-05-08)
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