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Albert Einstein College of Medicine, Bronx

H2-D^b molecule analysis shows other mechanisms involved in beta2m/type 1 diabetes relation

"Beta-2 microglobulin (beta 2m) is a member of the immunoglobulin-like domain superfamily that is an essential structural subunit of the MHC class I (MHC-I) molecule. beta2m was previously identified as a susceptibility factor for the development of type 1 diabetes (T1D) in NOD mice, whereby transgenic expression of the beta2m^a variant, but not the beta2m^b variant, restored diabetes susceptibility to normally resistant NOD.beta2m^null mice," researchers in the United States report.

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