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University of Hamburg
BH4 is a potential therapy for erectile dysfunction
May 8th, 2006
Tetrahydrobiopterin (BH4) is a potential therapy for erectile dysfunction (ED). "Nitric oxide (NO)-mediated smooth muscle relaxation causes penile erections. The endothelial NO synthase (eNOS) coenzyme tetrahydrobiopterin (BH4) converts eNOS-mediated catalytic activity from oxygen radical to NO production, improving endothelial function and vascular smooth muscle relaxation. Using quantitative immunohistochemistry, 8-isoprostane and nitrotyrosine concentrations were compared in cavernosal tissue from 17 potent and 7 impotent men, and the effect of single oral doses of BH4 on penile rigidity and tumescence was investigated," scientists writing in the Asian Journal of...
Source: Biotech Week (2006-05-08)
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