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Adrenal Tumors
Benign adrenal tumors not associated with microsatellite instability
September 20th, 2006
Benign adrenal tumors were not associated with microsatellite instability. "The adrenal gland may give rise to pheochromocytomas, which are catecholamine-producing tumors originating from the adrenal medulla, or to adrenocortical tumors, which derive from the adrenocortical cortex and may be secreting or not. The genetic mechanisms underlying the formation of these tumors include somatic mutations in susceptibility genes, especially in the familial forms, and allelic loss, especially in chromosome 1," investigators in France reported. "The aim of this study was to investigate a third genetic mechanism by evaluating microsatellite instability using...
Source: Biotech Week (2006-09-20)
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