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Allergy & Immunology
Activity of purified dust mite allergen crucially commits to sensitization process
September 20th, 2006
The activity of the purified house dust mite allergen crucially commits to the sensitization process. According to researchers in Japan, "The major proteolytic allergen derived from the house dust mite Dermatophagoides pteronyssinus, Der p1, is one of the most clinically relevant allergens worldwide. In the present study, we evaluate the contribution of the proteolytic activity and structure of a highly purified rDer p 1 to immune responses." "Mice were i.p. immunized with three forms of rDer p 1 adsorbed to alum: one enzymatically active, one treated with an irreversible cysteine protease-specific inhibitor, E-64, and one heat denatured,"...
Source: Biotech Week (2006-09-20)
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