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Allergy & Immunology
Hypoallergenic DNA vaccines were generated by using forced ubiquitination
September 20th, 2006
Scientists have generated hypoallergenic DNA vaccines by forced ubiquitination. According to recent research from Austria, "Hypoallergenic immunotherapy of type I allergies aims at inducing T-cell immunity while avoiding cross-linking of pre-existing IgE. DNA-based immunotherapy depends on the recruitment of antigen-specific TH 1 cells and therefore has to provide the whole repertoire of T-cell epitopes. Ubiquitination offers a general approach for the production of hypoallergenic DNA vaccines." A DNA-based vaccine encoding the major birch pollen allergen Bet v I stably linked to ubiquitin was evaluated for its anti-allergic potential in a...
Source: Biotech Week (2006-09-20)
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