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Allergy & Immunology
Neuropilin-1 transfer may encourage vascular remodeling during inflammation
September 20th, 2006
Neuropilin-1 (NRP1) transfer may encourage vascular remodeling during inflammation. According to recent research published in the Journal of Immunology, "NRP1 is a transmembrane protein expressed on neuronal and endothelial cells where it plays a crucial role in guiding axons and regulating angiogenesis. We have recently shown that NRP1 also is expressed on dendritic cells (DC) in the human immune system and have proposed a role for NRP1 in the first stages of the immune response." "In these studies, we show that NRP1 can be transferred with a high efficiency from human DC to T lymphocytes by trogocytosis. The NRP1 transfer can occur...
Source: Biotech Week (2006-09-20)
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