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Angiology
Bile acids induce adhesion molecule expression via ROS, NF-kappa B, and p38 activation
September 20th, 2006
Bile acids induce adhesion molecule expression in endothelial cells through activation of reactive oxygen species (ROS), NF-kappa B, and p38. According to a recent report from the United States, "Bile acids are synthesized in the liver, stored in gallbladder, and secreted into the intestine to aid in the absorption of lipid-soluble nutrients. In addition, bile acids also actively participate in regulation of gene expression through their ability to act as ligands for the nuclear receptor farnesoid X receptor or by activating kinase signaling pathways." "Under cholestatic conditions, elevated levels of bile acids in the liver induce hepatic...
Source: Biotech Week (2006-09-20)
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