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Angiology
C-reactive protein promotes platelet adhesion to endothelial cells, a pathway in atherothrombosis
September 20th, 2006
C-reactive protein promotes platelet adhesion to endothelial cells, which is a potential pathway in atherothrombosis. "C-reactive protein (CRP) is a strong predictor for acute cardiovascular events. Several endothelial prothrombotic effects of CRP have been recently reported," scientists in Israel reported. "This study examined the effect of CRP on bovine aortic endothelial cell (EC) activation and capacity to recruit human platelets under flow conditions using the cone and plate(let) analyser method. Human recombinant CRP promoted platelet adhesion in a dose-and time-dependent manner, with a maximal effect at 20 mc g/ml (increase of 174% over...
Source: Biotech Week (2006-09-20)
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