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Angiology
Mechanisms of nebivolol-induced vasodilation have been identified
September 20th, 2006
The endothelium-dependent NO liberation induced by nebivolol is due to stimulation of beta3 -adrenoceptors and oestrogen receptors and coincides with eNOS translocation and a phosphorylation at eNOS-serine 1177. According to research recently published in the journal Clinical and Experimental Pharmacology and Physiology, "Nebivolol (NEB) has been shown to be a selective blocker of beta1 -adrenoceptors with additional vasodilating properties that are mediated, at least in part, by an endothelial-dependent liberation of nitric oxide (NO)." "In the present study," wrote D. Ladage and colleagues at University of Cologne. "we...
Source: Biotech Week (2006-09-20)
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