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Apoptosis
Apoptosis is mediated by phosphorylation of eukaryotic translation initiation factor
September 20th, 2006
According to recent research from the United States, double-stranded RNA (dsRNA)-dependent protein kinase phosphorylation of the alpha-subunit of eukaryotic translation initiation factor 2 (eIF2) mediates apoptosis. "As the molecular processes of complex cell stress signaling pathways are defined, the subsequent challenge is to elucidate how each individual event influences the final biological outcome. Phosphorylation of the translation initiation factor 2 (eIF2 alpha) at Ser(51) is a molecular signal that inhibits translation in response to activation of any of four diverse eIF2 alpha stress kinases. "We used gene targeting to replace the wild-type...
Source: Biotech Week (2006-09-20)
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