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Apoptosis
Apoptosis resistance of hepatic stellate cells involves protein overexpression
September 20th, 2006
Recent research from Italy has documented that apoptosis resistance of hepatic stellate cells (HSC) involves protein overexpression. "Myofibroblast-like cells, originating from activation of hepatic stellate cells (HSC/MFs), play a key role in liver fibrosis, a potentially reversible process that may rely on induction of HSC/MFs apoptosis. While this possibility has been shown in cultured rat HSC, very limited data are currently available for human HSC/MFs," wrote E. Novo and colleagues, University of Turin. "Cultured human HSC/MFs were exposed to several proapoptotic stimuli, including those known to induce apoptosis in rat HSC/MFs, and induction of...
Source: Biotech Week (2006-09-20)
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