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Apoptosis
Epithelial apoptosis involves release of complement membrane cofactor protein
September 20th, 2006
Recent research from Finland has chronicled a disintegrin and metalloproteinase (ADAM) 10-mediated release of complement membrane cofactor protein during apoptosis of epithelial cells. "Membrane cofactor protein CD46 controls complement activation on cells, is a receptor for several pathogens, and modulates immune responses by affecting CD8+ T cells. Cells can release CD46 in an intact form on membrane vesicles and in a truncated form by a metalloproteolytic cleavage. "The mechanism of shedding and its relationship to cell physiology has remained unclear. We have found using RNA interference analysis that ADAM10 is responsible for the regulated...
Source: Biotech Week (2006-09-20)
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