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Acute Myeloid Leukemia
Acute myeloid leukemia cell beta-catenin expression predicts poor prognosis
September 20th, 2006
Acute myeloid leukemia cell beta-catenin expression predicts enhanced clonogenic capacities and poor prognosis. According to recently published research from France, "Activation of the Wnt/beta-catenin pathway has recently been shown to be crucial to the establishment of leukemic stem cells in chronic myeloid leukemia. "We sought to determine whether beta-catenin was correlated to clonogenic capacity also in the acute myeloid leukemia (AML) setting. Eighty-two patients were retrospectively evaluated for beta-catenin expression by Western blot." "beta-Catenin was expressed (although at various protein levels) in 61% of patients,"...
Source: Biotech Week (2006-09-20)
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