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Addiction Medicine
Central excitatory effects of intravenous cocaine are related to Na+ channels
October 25th, 2006
According to recent research from the United States published in the European Journal of Neuroscience, the central excitatory effects of intravenous cocaine (COC) are related to Na+ channels. "While alterations in dopamine (DA) uptake appear to be a critical mechanism underlying locomotor and reinforcing effects of COC, many centrally mediated physiological and affective effects of this drug are resistant to DA receptor blockade and are expressed more quickly following an intravenous (i.v.) injection than expected based on the dynamics of drug concentration in the brain," wrote P.L. Brown and colleagues of the U.S. National Institute of Drug Abuse....
Source: Biotech Week (2006-10-25)
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