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Adenovirus Vector
Gene transfer of IGF-I to joint synovium elevates IGF-I ligand in synovial fluid
October 25th, 2006
Direct adenovirus-mediated insulin-like growth factor-I gene transduction of the synovium of joints induces persistent synovial fluid IGF-I ligand elevations. According to a report from the United States, "Insulin-like growth factor-I (IGF-I) is one of the most influential growth factors in cartilage repair. Maintenance of adequate IGF-I levels after articular repair procedures is complicated by the short biological half-life of IGF-I in vivo." L.R. Goodrich and colleagues at Cornell University wrote, "This study investigated the potential for more prolonged IGF-I delivery through direct adenoviral mediated transduction of synovial tissues in the...
Source: Biotech Week (2006-10-25)
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