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Adenovirus-Mediated Gene Therapy
Replication-defective recombinant UGT1A adenovirus selectively restores hepatic UGT1A function
October 25th, 2006
Replication-defective recombinant UGT1A adenovirus selectively restores hepatic UGT1A function. "The Gunn rat has been a valuable model for investigating the effect of UDP-glucuronosyltransferase 1A (UGT1A) deficiencies on drug metabolism and toxicity, but it is limited in some aspects. For example, the native Gunn rat model cannot distinguish between hepatic and extrahepatic UGT1A deficiencies in toxicological mechanisms. To extend the model's utility, we investigated the use of replication-defective recombinant UGT1A adenoviruses for the purpose of selectively restoring hepatic UGT1A function," scientists in the United States report. K.K. Miles and...
Source: Biotech Week (2006-10-25)
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