Hyperhomocysteinemia

New Hyperhomocysteinemia Research from Idaho State University Outlined

Published in Biotech Week, September 14th, 2011

2011 SEP 14 -- "Hyperhomocysteinemia (HHcy) increases permeability of the blood-brain barrier, but the mechanisms are undetermined. Homocysteine (Hcy) is an agonist of the neuronal N-methyl-D-aspartate receptor (NMDAr)," scientists in Pocatello, Idaho report.

"We tested the hypothesis that HHcy disrupts the blood-brain barrier by an NMDAr-dependent mechanism in endothelium. In brain microvascular endothelial cells, there was no change in expression of the adherens junction protein VE-cadherin with Hcy treatment, but there was a significant decrease in the amount of beta-catenin at the membrane. Moreover, Hcy caused nuclear translocation of beta-catenin and...

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Source: Biotech Week (2011-09-14)

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