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Phosphoprotein Phosphatases

Study Findings from Kobe University School of Medicine Provide New Insights into Phosphoprotein Phosphatases

Published in Biotech Week, November 16th, 2011

2011 NOV 16 -- Researchers detail in "Genome-wide screening for genes associated with FK506 sensitivity in fission yeast," new data in Phosphoprotein Phosphatases. "We have been studying calcineurin signal transduction pathway in fission yeast Schizosaccharomyces pombe (S. pombe) by developing a genetic screen for mutants that show hypersensitivity to the immunosuppressive calcineurin inhibitor FK506 (tacrolimus). In the present study, to identify nonessential genes that are functionally related to the calcineurin signaling pathway, we performed a genome-wide screen of 3004 haploid deletion strains and confirmed 72 deletion strains to be FK506 sensitive," scientists in Kobe,...

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