Alcohol Oxidoreductases
Studies from University of Pennsylvania Yield New Data on Alcohol Oxidoreductases
Published in Biotech Week, April 11th, 2012
2012 APR 11 -- Investigators discuss in "Development of Potent and Selective Inhibitors of Aldo-Keto Reductase 1C3 (Type 5 17ß-Hydroxysteroid Dehydrogenase) Based on N-Phenyl-Aminobenzoates and Their Structure-Activity Relationships" new findings in Alcohol Oxidoreductases. "Aldo-keto reductase 1C3 (AKR1C3; type 5 17ß-hydroxysteroid dehydrogenase) is overexpressed in castration resistant prostate cancer (CRPC) and is implicated in the intratumoral biosynthesis of testosterone and 5a-dihydrotestosterone. Selective AKR1C3 inhibitors are required because compounds should not inhibit the highly related AKR1C1 and AKR1C2 isoforms which are involved in the inactivation of...
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Source: Biotech Week (2012-04-11)
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