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Studies from Washington University School of Medicine Yield New Information about Life Science

Published in Biotech Week, April 11th, 2012

2012 APR 11 -- Current study results from the report, "Characteristics of concatemeric GABA(A) receptors containing a4/d subunits expressed in Xenopus oocytes," have been published. According to the authors of recent research from St. Louis, Missouri, "GABA(A) receptors mediate both synaptic and extrasynaptic actions of GABA. In several neuronal populations, a4 and d subunits are key components of extrasynaptic GABA(A) receptors that strongly influence neuronal excitability and could mediate the effects of neuroactive agents including neurosteroids and ethanol."

"However, these receptors can be difficult to study in native cells and recombinant d subunits...

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