Published in Bioterrorism Week, July 4th, 2005
"Density-dependent gene expression, quorum sensing (QS), involves the synthesis and detection of low-molecular-weight molecules known as autoinducers. Inhibitors of bacterial QS systems offer potential treatment of infections with highly virulent or multidrug-resistant agents," investigators in the United States report.
"We studied the effects on Bacillus anthracis growth and the virulence gene (pagA, lef, and cya) expression of the QS inhibitor (5Z)-4-bromo-5-(bromo-methylene)3-butyl-2(5H)-furanone, which is naturally synthesized by the marine alga Delisea...
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