Published in Blood Weekly, February 13th, 1995
TM is the anticoagulant endothelial cell membrane-bound protein cofactor in the thrombin-mediated activation of protein C (PC), and the PC system's anticoagulant and profibrinolytic functions are important in preventing a thromboembolic disease. Thromboembolic diseases develop in patients with PC, protein S or PC cofactor deficiency and/or dysfunction. The molecular abnormality in at least 20 to 30 percent of thrombophilic patients, however, cannot be identified by previously recognized defects.
Ann-Kristin Ohlin, University Hospital, Lund,...
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