Conference Coverage

Clinical Trial of Transdominant Rev Underway

Published in Blood Weekly, February 20th, 1995

Three patients with HIV infection have received five transfers of autologous T cells carrying a gene construct - Rev M10 - that suppresses HIV replication without affecting T-cell function.

All three patients have received transfers of at least 1 billion cells, and two have received transfers of 10 billion cells. In all, 12 patients are enrolled in the Phase I study, reported University of Michigan researcher Gary Nabel at the 2nd National Conference on Human Retroviruses and Related Infections, held January 29-February 2, 1995, in Washington, D.C.

The Rev M10 construct is one of three anti-HIV gene therapy strategies currently in Phase I clinical...

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Source: Blood Weekly (1995-02-20)

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