International/Asia - HCV Genomic Variants
"Prevalence of Hepatitis C Virus Sequence Variants in South-East Asia."
Published in Blood Weekly, March 27th, 1995
According to the authors' abstract of an article published in Journal of General Virology, "The nature and distribution of hepatitis C virus (HCV) genotypic variants present in south-east Asia have not been extensively investigated. We analyzed HCV RNA obtained from 67 clinical serum samples from Singapore, Thailand, Indonesia, the Philippines and South Korea. All samples were amplified by semi-nested RT-PCR and the nucleotide sequence determined for four regions within the E1, E2/NS1, NS4 and NS5 genes. Each isolate had a unique nucleotide and deduced amino acid sequence, consistent with the genetic heterogeneity of this virus. There was remarkably little amino acid sequence variation...
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Source: Blood Weekly (1995-03-27)
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