Leukemia

B7-1 Gene Transfer Confers Protective and Therapeutic Immunity

Published in Blood Weekly, May 15th, 1995

Researchers report that transduced B7-1 gene in a myeloid leukemic cell line confers protective and therapeutic immunity against established B7-1 negative leukemia in a murine model.

Results from a study conducted by Ursula A. Matulonis et al. indicate that human myeloid leukemic cells may be attractive candidates for B7-1 gene transfer ("Role of B7-1 in Mediating an Immune Response to Myeloid Leukemia Cells," Blood, May 1, 1995;85(9):2507-15).

Matulonis et al. developed a model system with a rapidly lethal, nonimmunogenic, myeloid leukemic cell line, 32Dp210/B7-1/clone 2, that would allow them to determine the utility of the transduced costimulatory...

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Source: Blood Weekly (1995-05-15)

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