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Leukemia

Better Understanding of Immune System Evasion Mechanism Sought

Published in Blood Weekly, May 15th, 1995

A better understanding of how myeloid leukemia escapes immune surveillance is being sought by Minnesota researchers.

M.W. Boyer et al., from the University of Minnesota Hospital and Clinic, examined the in vitro and in vivo host immune responses to a murine acute myelogenous leukemia (AML) cell line ("Dependency on Intercellular Adhesion Molecule Recognition and Local Interleukin-2 Provision in Generation of an in Vivo CD8+ T-Cell Immune Response to Murine Myeloid Leukemia," Blood, May 1, 1995;85(9):2498-2506).

Their study was done utilizing an AML cell line, C1498, which had arisen spontaneously and had therefore, escaped the host's...

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