Borrelia Burgdorferi

OspA Appears Protective Against Lyme Disease

Published in Blood Weekly, May 29th, 1995

Murine trials suggest that vaccination with outer surface protein A is protective against Lyme disease.

Antibodies produced against the major outer surface protein A (OspA) of Borrelia burgdorferi, the etiologic agent of Lyme disease, appear to protect mice from infections and disease. Virtually all mice receiving such preparations were protected against infection on challenge with virulent homologous-strain spirochetes, as determined by culture and histopathology of internal tissues, but were susceptible to challenge with some heterologous strains.

"These successful experiments, however, have generally used immunogens that would be...

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Source: Blood Weekly (1995-05-29)

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