"Human MAbs Reactive with Public Determinants on HLA Class 1 Antigens."

According to an abstract submitted by the authors to the 4th International Conference on Human Antibodies and Hybridomas, held April 26-28, 1995, in Amsterdam, The Netherlands, "Many serological studies on allospecific sera have shown the existence of public determinants to allelic HLA A-locus or B-locus products. A precise definition of such public determinants is difficult because virtually all allosera contain mixtures of antibodies. We have established a number of human hybridomas producing specific antibodies reactive with public determinants. Peripheral blood lymphocytes from parous women whose sera contained a variety of HLA alloantibodies, were EBV transformed and cultured in...

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