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Transplantation/Bone Allograft

First Case of Alloimmunization to Antigens Other than Those in ABH or Rh Systems

Published in Blood Weekly, July 10th, 1995

Alloimmunization to blood group antigens other than ABO and Rh may occur after bone allografting.

The first report of such an occurrence was described by R.F. Cheek, M.D., Massachusetts General Hospital, Boston, Massachusetts, and colleagues ("Red Cell Alloimmunization after a Bone Allograft," Transfusion, June 1995;35(6):507-509).

"Alloimmunization to blood group antigens other than ABH after bone allografting is uncommon," noted Cheek et al. "To date, examples of alloimmunization to blood group antigens other than ABH have been limited to the Rh system.

The case patient, a 20-year-old woman, received an allogeneic bone graft...

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