Published in Blood Weekly, July 31st, 1995
CML is a neoplastic disorder of the hematopoietic stem cell in which the leukemic cells have a specific chromosomal defect termed the Philadelphia (Ph) chromosome. This chromosome is characterized by a translocation that results in the fusion of c-abl and the major bcr genes. The BCR-ABL tyrosine kinase has enhanced activity over wild-type c-ABL and is thought to play a central role in CML pathogenesis.
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