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Transplantation/Bone

Chemical Decontamination Is Required for Safe Allograft Procedures

Published in Blood Weekly, August 7th, 1995

Simian immunodeficiency virus (SIV, HIV-II) can be transmitted in bone allograft procedures, despite freeze-thaw cycles and lavaging to remove blood elements.

In order to provide a high level of confidence in the safety of allograft bone procedures, chemical decontamination appears necessary, stated Stephen D. Cook, Ph.D., and colleagues, Tulane University School of Medicine, New Orleans, Louisiana.

Cook et al. used rhesus monkeys (Macaca mulatta) that were infected with SIV in order to study disease transmission in allograft bone and to find if processing techniques could eliminate the potential for disease transmission ("Simian...

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