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Transfusion

Autoimmune Disease in Women Is a Factor in RBC Alloantibody Development

Published in Blood Weekly, August 28th, 1995

Autoimmune disease often is an underlying factor in women who develop multiple or uncommon red cell (RBC) alloantibodies that have potential clinical significance.

Patients with such antibodies can present challenges to blood banks and require special efforts, indicated Glenn Ramsey, Northwestern University Medical School, Chicago, Illinois, and Sandra J. Smietana, Genesis Clinical Laboratories, Berwyn, Illinois. Immunohematology reference laboratories and rare blood donor registries extend much effort and provide expertise to support the transfusion needs of these patients. However, little is understood regarding why some patients develop antibodies following...

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