"Ultrapure Polymerized Bovine Hemoglobin (UPPBHb) Improves Integrity of the Isolated Perfused Rat Kidney (IPRK): Effects on Function and Structure."

According to the authors' abstract of an article published in Clinical Nephrology, "To test the oxyphoretic properties and potential nephrotoxic side-effects of polymerized hemoglobin solutions, isolated rat kidneys were perfused in a recirculating system for 180 min. Group I was perfused with a substrate enriched Ringer solution containing hydroxyethylstarch (HES) to produce isoncotic conditions. In group II HES was substituted in part by UPPBHb (34 g/l) with a high portion of low molecular weight molecules (= UPPBHb1). In group III 34 g/l of UPPBHb containing an increased fraction of high molecular weight polymers (= UPPBHb2) was used. Only UPPBHb2-perfused kidneys showed a reduced...

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